Systemic Hydra & Lipid-Replenisher
Skin Holobiont Invigorator

GREENTECH INNOVATION

• Systemic hydra & lipid-replenisher: from dermis to skin surface
• Skin holobionte invigorator: stimulated skin host-microbiota interactions – metaproteomic analysis
• Advanced fermentation process: wild yellow gentian (sustainably & locally harvested in France) enhanced by fermentation with a rare and resistant bacteria from aerobiome

Purified extract of organic wild yellow gentian roots (Gentiana lutea) enhanced by an advanced and upcycled fermentation process with a rare and cold-tolerant bacteria from aerobiota

The wild yellow gentian is sustainably and locally harvested in France by gentian-pickers trained in good harvesting practices, gentian roots are strictly selected by GREENTECH scientists.
The bacteria (Sphingomonas sp.), also sourced in France, has de ability to survive in a cold and more desiccated air environment thanks to specific defense mechanisms.

HOLOBIOSYS® is the latest achievement of more than 30 years of Greentech research. Thirty robust years of expertise in various fields: biotechnologies, metabolically oriented fermentation, phytochemistry, green extraction, biomimetism and microbiota.

Today, our extensive scientific approach allows to unveil a new generation of active ingredients for cosmetics. Utilizing an innovative metaproteomic study which focuses on the specific function of each cellular protein. A major advance in cosmetics! Our systemic method treats the skin as a whole and repairs conditions of dry and dehydrated skin via a boost of hyaluronic acid and skin lipids synthesis.

We are convinced that ecosystems must be studied as a whole, focusing on the interconnections between their various components rather than on the individual parts. Taking it a step further than a simple microbiota study comparing one side and the skin to the other, the study of the holobiont provides a comprehensive view of the interactions between the skin and its microbial ecosystem.

Understanding and mastering the holobiont is a scientific achievement for Greentech. An innovation that moves science forward and provides a next generation of skin care actives: more specific, more sustainable and ever more effective.

HOLOBIOSYS is a COSMOS-certified organic and microbiota-friendly active ingredient. A wild yellow gentian roots extract enhanced by fermentation with a rare and cold-tolerant bacteria from aerobiota.

To counteract dehydrated (lack of water) and dry (lack of lipids) skin, HOLOBIOSYS^® boosts hyaluronic acid (HA) synthesis both in the epidermis and the dermis. It also stimulates HA receptor CD44 and its signaling cascade allowing the reinforcement of epidermal barrier. 

Indeed, tight junction and differentiation markers are upregulated as well as lipid synthesis in keratinocytes for a more cohesive epidermis able to lock in skin moisture. HOLOBIOSYS^® also stimulates dermal-epidermal junction markers expression for a better diffusion of water bound to HA within the skin.  Finally, antioxidant cell responses are upregulated after treatment with HOLOBIOSYS^® both in keratinocytes and fibroblasts for a protection against HA degradation by free radicals.

Clinically tested on volunteers with dehydrated skin, HOLOBIOSYS^® increases skin hydration index after 28 days of application at 1% vs placebo and smoothes wrinkles. It also protects hydrolipidic film and has even a lipid-replenishing effect on a sub-panel presenting dehydrated and sebum-deficient skin.

Clinically tested on volunteers with dehydrated skin, HOLOBIOSYS^® increases skin hydration index after 28 days of application at 1% vs placebo and smoothes wrinkles. It also protects hydrolipidic film and has even a lipid-replenishing effect on a sub-panel presenting dehydrated and sebum-deficient skin.

With HOLOBOSYS^®, GREENTECH R&D goes a step further by studying the skin holobiont (the assemblage between the skin and its microbiota) with an innovative and emerging cutting edge technology: a metaproteomic study.

With age and loss of hydration, the Greentech research shows that there is a slow-down of skin barrier and antioxidant functions both from human and microbial origins. By focusing on the host/microbiota interactions, HOLOBIOSYS^® stimulates these functions and contribute to a more harmonized and invigorated holobiont, allowing a deep hydration-restructuring action. 

APPLICATIONS